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Wednesday, July 17, 2013

Amoxycillin for animal Respiratory and Gastrointestinal tract infections. -Cystitis & dermatitis.



Amoxycillin 20 %
Each 100 gm contains: Amoxycillin activity 20 gm ( Equivalent to 23 gm Amoxycillin trihydrate)

Company Name
CID

Pharmaceutical form
Water Soluble Powder

Package
Tins of 200 gm or 500 gm.

Indications
For treatment and control infections caused by or associated with Amoxycillin sensitive organisms in most species of domestic animals and birds, including infections of GIT, respiratory tract and Urogenital tract with the following pathogens: Streptococci, Staphylococci, Salmonella spp., Escherichia coli, Pasteurella spp., Haemophilus spp. and Proteus mirabilis.

Warning & Precautions
Operators with known hypersensitivity should not handle the drug.

Product Type
Vet.

Dosage
Amoxycillin is administered via oral route in the following dosage:
For active ingredient :
• Calves : 8 mg / kg twice daily.
• Cats & Dogs: 10 mg/kg twice daily.
• Poultry : (15-20) mg/kg by addition to drinking water.
• Pigeons & ducks : 20 mg/kg by addition to drinking water.
• Horses : (20-30) mg/kg 2 times daily.
For whole product :
• Calves: 40 mg / kg twice daily.
• Cats & Dogs: 50 mg / kg twice daily.
• Poultry: (75-100) mg / kg by addition to drinking water.
• Pigeons & ducks: 100 mg / kg by addition to drinking water.
• Horses: (100-150) mg / kg twice daily. N.B :
- Duration of treatment is about 3-6 days.
- When given via drinking water, remove all other sources of water until the medicated water has been consumed.
Withdrawal period:
Slaughter: Poultry: - Chicken after 2 days
- Turkeys after 5 days
- Ducks after 9 days
Calves: after 20 days.

Adverse Reactions
Allergic reactions and diarrhea may occur.

Contra Indications
• Should not be given to ruminants with functional rumens to avoid possible disturbance of ruminal flora. • In case of penicillin or cephalosporin hypersensitivity. • Should not be used for birds producing egg for human consumptions.

Drug Interactions
Concurrent adminstration of salicylates, phenylbutazone, sulfonamide and other weak acids delayed amoxicillin tubular secreation .


Amoxycillin 20 %

Amoxycillin anhydrous 20 %
Company Name
ADCO
 
Pharmaceutical form
Powder
 
Package
The packs of 100 gm , 250 gm ,500 gm, 1 kgm powder.
 
Indications
-Respiratory tract infections. -Gastrointestinal tract infections. -Cystitis & dermatitis.
 
Warning & Precautions
-Do not administer systemic antibiotics orally in patients with septicemia, shock, or other grave illness as absorption of the medication from the GI tract may be delayed or diminished. -Penicillins have been shown to cross the placenta and safe use of them during pregnancy has not been firmly established
 
Product Type
Veterinary
 
Dosage
Dogs & Cats: For susceptible infections : For gram + ve infections :10 mg /kgm PO twice daily. For gram - ve infections : 20 mg/kgm PO three times daily. continue for at least 2 days after all symptoms have subsided. Horses: For respiratory infections : 20 - 30 mg/kgm PO every 6 hours . Birds: For susceptible infections For most species: 150 -175 mg/kgm PO once to twice daily 100 mg/kgm PO every 8 hours . Cattle: Calves: Amoxycillin trihydrate: 7 mg/kgm PO from 8 - 12 hours Rabbits & Rodents: Hedgehogs: 15 mg/kgm PO every 12 hours . Reptiles: For all species : 22 mg /kgm PO every 12- 24 hours, not very useful unless used in combination with aminoglycosides . Ferrets : For eliminating helicobacter gastritis infections : using triple therapy: Amoxycillin 22 mg/kgm Metronidazole 22 mg/kgm Bismuth salicylate 17.6 mg/kgm PO three times daily.
 
Adverse Reactions
-Adverse effects with the penicillins are usually not serious and have a relatively low frequency of occurrence. -When given orally penicillins may cause GI effects (anorexia vomiting diarrhea). Because the penicillins may also alter gut flora antibiotic-associated diarrhea can occur, as well as selecting out resistant bacteria maintaining residence in the colon of the animal (super infections). -Hypersensitivity reactions unrelated to dose can occur with these agents and can be manifested as rashes, fever, eosinophilia, neutropenia , agranulocytosis, thrombocytopenia, leukopenia . -High doses or very prolonged use has been associated with neurotoxicity ataxia in dogs) although the penicillins are not considered to be hepatotoxic elevated liver enzymes have been reported other effects reported in dogs include tachypnea, dyspnea , edema and tachycardia.
 
Contra Indications
-Penicillins are contraindicated in animals which have a history of hypersensitivity to them. -Because there may be cross-reactivity, use penicillins cautiously in animals which who are documented hypersensitive to other beta-lactam antibiotics .
 
Drug Interactions
None



Amoxycillin 30 %

Each 100 gm contains : Amoxycillin anhydrous 30 gm
Company Name
ADCO
 
Pharmaceutical form
Powder
 
Package
The cans of 100 gm , 250 gm ,500 gm, 1 kgm powder.
 
Indications
-Respiratory tract infections. -Gastrointestinal tract infections. -Cystitis & dermatitis Target species: Dogs, Cats, Rabbits, Rodents, Horse, Ferrets , Reptiles, Birds.
 
Warning & Precautions
None
 
Product Type
VETERINARY
 
Dosage
Dogs & Cats: For susceptible infections : For gram + ve infections :10 mg /kgm PO twice daily. For gram - ve infections : 20 mg/kgm PO three times daily. continue for at least 2 days after all symptoms have subsided. Horses: For respiratory infections : 20 - 30 mg/kgm PO every 6 hours . Birds: For susceptible infections For most species: 150 -175 mg/kgm PO once to twice daily 100 mg/kgm PO every 8 hours . Cattle: Calves: Amoxycillin trihydrate: 7 mg/kgm PO from 8 - 12 hours Rabbits & Rodents: Hedgehogs: 15 mg/kgm PO every 12 hours Reptiles: For all species : 22 mg /kgm PO every 12- 24 hours, not very useful unless used in combination with aminoglycosides . Ferrets : For eliminating helicobacter gastritis infections : using triple therapy: Amoxycillin 22 mg/kgm Metronidazole 22 mg/kgm Bismuth salicylate 17.6 mg/kgm PO three times daily.
 
Adverse Reactions
-Adverse effects with the penicillins are usually not serious and have a relatively low frequency of occurrence. -When given orally penicillins may cause GI effects (anorexia vomiting diarrhea). Because the penicillins may also alter gut flora antibiotic-associated diarrhea can occur, as well as selecting out resistant bacteria maintaining residence in the colon of the animal (super infections). -Hypersensitivity reactions unrelated to dose can occur with these agents and can be manifested as rashes, fever, eosinophilia, neutropenia , agranulocytosis, thrombocytopenia, leukopenia . -High doses or very prolonged use has been associated with neurotoxicity ataxia in dogs) although the penicillins are not considered to be hepatotoxic elevated liver enzymes have been reported other effects reported in dogs include tachypnea, dyspnea , edema and tachycardia.
 
Contra Indications
-Penicillins are contraindicated in animals which have a history of hypersensitivity to them. -Because there may be cross-reactivity, use penicillins cautiously in animals which who are documented hypersensitive to other beta-lactam antibiotics .
 
Drug Interactions
None
5 Vet Drug Index: Amoxycillin for animal Respiratory and Gastrointestinal tract infections. -Cystitis & dermatitis. Amoxycillin 20 % Each 100 gm contains: Amoxycillin activity 20 gm ( Equivalent to 23 gm Amoxycillin trihydrate) Company Name CID Ph...

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