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Wednesday, July 17, 2013

Ampicillin for veterinary use


Ampicillin 4 gm
Each vial contains:
Ampicillin (as sodium salt ) 4 gm
( Equivalent to 4.3 gm Ampicillin sodium).

Company Name
CID

Pharmaceutical form
Vials

Package
Vials of 4 g

Indications
Ampicillin is used for treatment of the following entities in the following species:
Calves:
- Calf scours and pneumonia.
- Calf enteritis and septicemia due to Salmonella infection.
- Mastitis due to E.coli infections, foul of the foot, metritis and pyelonephritis.
Foals:
- Enteritis and septicemia in the new born and young foals.
- Respiratory infections particularly in association with equine influenza.
- Metritis.
Dogs:
- Secondary infection associated with dermatitis and post operative wounds.
- Enteritis, ear infections, leptospirosis.
- Pharyngitis, tonsillitis and respiratory infection.
- Urogenital infections.
Cats:
- Secondary infections associated with respiratory viruses.
- Enteritis and ear infections.

Warning & Precautions
- Operators with known hypersensitivity to penicillin or cephalosporin should not handle the drug. - Not to be used for lactating animals.

Product Type
Vet.

Dosage
The powder is to be dissolved in 20 ml water for injection immediately before use.
For active ingredient:
7.5 mg/kg once daily either by I.M. or S.C. injection for cats and dogs.
7.5 mg/kg once daily by I.M. injection for other species.
For whole product:
8 mg/kg once daily either by I.M. or S.C. injection for cats and dogs.
8 mg/kg once daily by I.M. injection for other species.
Withdrawal period:
Meat producing animals: 18 days.

Adverse Reactions
- Allergic reactions and diarrhea may occur.
- Occasional irritation at the site of injection.

Contra Indications
- Small herbivorous such as rabbits, gerbils and hamsters.
- Hypersensitivity to penicillin or cephalosporin.
- Not to be injected intrathecal.



Ampicillin 20 % .

Each 100 gm contains : Ampicillin anhydrous 20 gm
Company Name
ADCO
 
Pharmaceutical form
Powder
 
Package
Packs of 100 gm, 250 gm, 500 gm and 1 kgm
 
Indications
-In dogs and cats, Ampicillin is not well absorbed after oral administration -Penicillins are usually bactericidal against susceptible bacteria and act by inhibiting mucopeptide synthesis in the cell wall resulting in a defective barrier and an osmotically unstable spheroplast . -Penicillins have been used for a wide range of infections in various species.
 
Warning & Precautions
-Do not administer systemic antibiotics orally in animals with septicemia, shock, or other grave illness as absorption of the medication from the GI tract may be delayed or diminished. -Penicillins have been shown to cross the placenta and safe use of them during pregnancy has not been firmly established.

Product Type
VETERINARY
 
Dosage
Dogs & Cats: For gram + ve infections :10 -20 mg /kgm PO twice daily of Ampicillin anhydrous (equiv. to 50 -100 mg /kgm) of the whole product For gram – ve infections : 20 -30 mg kgm PO three times daily of Ampicillin anhydrous (equiv. to 100 -150 mg /kgm) of the whole product Rodents: 20 - 100 mg /kgm PO daily from 8 – 12 hours of Ampicillin anhydrous (equivalent to 100 -500 mg /kgm) of the whole product. Cattle: 4 - 10 mg /kgm PO from 12-24 hours of Ampicillin anhydrous (equiv. to 20 -50 mg /kgm) of the whole product . Reptiles: all species : 3-6 mg /kgm PO from 12-24 hours for 2 weeks of Ampicillin anhydrous (equiv.to 15 -30 mg /kgm) of the whole product . -Not very useful unless used in combination with aminoglycosides Birds: For susceptible infections: Chickens : 1.65 gm /L drinking water of Ampicillin anhydrous (equivalent to 8.25 mg /L ) of the whole product. Most birds: 250 mg /kgm via feed for 5 -10 days of Ampicillin anhydrous (equivalent to 1.25 gm /kgm) of the whole product, sprinkle on favorite food Note : Duration of treatment are general guidelines, generally treat for at least 2 days after all signs of infection are gone.
 
Adverse Reactions
-Adverse effects with the penicillins are usually not serious and have a relatively low frequency of occurrence. -When given orally, penicillins may cause GI effects (anorexia, vomiting & diarrhea). because the penicillins may also alter gut flora, antibiotic associated diarrhea can occur. as well as selecting out resistant bacteria maintaining residence in the colon of the animal (super infections). -Hypersensitivity reactions unrelated to dose can occur with these agents and can be manifested as rashes, fever, eosinophilia, neutropenia, agranulocytosis, thrombocytopenia, leucopenia. -High doses or very prolonged use has been associated with neurotoxicity (ataxia in dogs). although the penicillins are not considered to be hepatotoxic, elevated liver enzymes have been reported. Other effects reported in dogs include tachypnea, dyspnea, oedema and tachycardia.
 
Contra Indications
-Penicillins are contraindicated in animals which have a history of hypersensitivity to them. -Because there may be cross-reactivity, use penicillins cautiously in animals which are documented hypersensitive to other beta-lactam antibiotics.
 
Drug Interactions
None
5 Vet Drug Index: Ampicillin for veterinary use Ampicillin 4 gm Each vial contains: Ampicillin (as sodium salt ) 4 gm ( Equivalent to 4.3 gm Ampicillin sodium). Company Name CID...

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